One symptom you need to look out for is jaundice, which occurs when your eyes and skin take on a yellow hue. It’s often the first sign of pancreatic cancer. Jaundice occurs when bilirubin, which is created in the liver, builds up. Bilirubin is typically eliminated by the liver in bile, but it can build up if the bile duct is blocked by a tumor. This is usually the result of cancer starting in the head of the pancreas, and as it spreads, it can work its way to the liver, which then leads to jaundice.